Open Contents
-
PMC OpenAccess
Subject 의과학, 인문사회과학 Source PMC OpenAccess URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010144/view Article Title Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays.Authors I. R. MajorAbstract A curvilinear dose response of myeloid leukaemia induction in the CBA male mouse was obtained after single whole-body X-irradiation at about 3 months of age. This strain has a very low spontaneous incidence of the disease and no cases were found in the unirradiated controls. The incidence was independent of dose rate over the range used (4.2-552 rad/min). Diagnosis required histopathological examination of various body tissues, the gross anatomical changes being easily confused with other haemopoietic disorders, but a few cases were recognized in life from blood samples. Curve-fitting to various models based on theories of radiocarcinogenic mechanism is described. Images Fig. 1 Fig. 3 Fig. 4 Fig. 5Is Part Of British Journal of Cancer 1979-12-01 , Vol.40 (6) , 903-913 Identifier ISSN: 1532-1827, 0007-0920 Category -
PMC OpenAccess
Subject 의과학, 인문사회과학 Source PMC OpenAccess URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010138/view Article Title The Story of CancerAuthors F. J. C. RoeIs Part Of British Journal of Cancer 1979-12-01 , Vol.40 (6) , 962-963 Identifier ISSN: 1532-1827, 0007-0920 Category -
PMC OpenAccess
Subject 의과학, 인문사회과학 Source PMC OpenAccess URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010154/view Article Title Natural cytotoxic macrophages in the peritoneal cavity of mice.Authors E. Pels; W. Den OtterAbstract Many strains of mice from various breeding institutes have natural cytotoxic macrophages. These macrophages can also be present in nude mice, suggesting that this cytotoxicity can be acquired without invovlvement of T cells. The natural cytotoxicity was non-specific for tumour cells, was not sensitive to trypsin treatment, was lost after 5 days incubation, but could be enhanced by foetal bovine serum. The presence of cytotoxic macrophages in the peritoneal cavity was not genetically or age controlled. Natural cytotoxic macrophages did not occur in germ-free mice. The possible causes of natural cytotoxicity are discussed.Is Part Of British Journal of Cancer 1979-12-01 , Vol.40 (6) , 856-861 Identifier ISSN: 1532-1827, 0007-0920 Category -
PMC OpenAccess
Subject 의과학, 인문사회과학 Source PMC OpenAccess URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010133/view Article Title Gastrointestinal Tract CancerAuthors W. DuncanIs Part Of British Journal of Cancer 1979-12-01 , Vol.40 (6) , 962-962 Identifier ISSN: 1532-1827, 0007-0920 Category -
PMC OpenAccess
Subject 의과학, 인문사회과학 Source PMC OpenAccess URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010140/view Article Title Changes in NMR relaxation times of adjacent muscle after implantation of malignant and normal tissue.Authors C. R. Ling; M. A. Foster; J. R. MallardAbstract In separate experiments, normal foreign tissue and malignant tumour were implanted s.c. into the rat thigh. NMR T1 values of the adjacent normal muscle, resulting from local inflammatory reactions or from malignant invasion, were measured. Elevations in T1 of the underlying muscle occurred within 24 h in both experiments, and it is believed these were caused by rapid inflammatory and immunological reactions to the implants. However the T1 values of muscle samples adjacent to the non-malignant implants decreased during the 11 days after implantation, dropping to values within the normal range. In the second experiment there was progressive malignant invasion into the normal adjacent tissue and the elevated T1 values were maintained throughout the 12-day period. The effects of the implantation on tissue water content are discussed in relation to NMR T1 relaxation times, and the relevance to whole-body NMR imaging of elevated T1 values due to nonmalignant pathological states is considered.Is Part Of British Journal of Cancer 1979-12-01 , Vol.40 (6) , 898-902 Identifier ISSN: 1532-1827, 0007-0920 Category -
PMC OpenAccess
Subject 의과학, 인문사회과학 Source PMC OpenAccess URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010145/view Article Title Electron Microscopy in Human MedicineAuthors T. D. AllenIs Part Of British Journal of Cancer 1979-12-01 , Vol.40 (6) , 957-957 Identifier ISSN: 1532-1827, 0007-0920 Category -
PMC OpenAccess
Subject 의과학, 인문사회과학 Source PMC OpenAccess URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010126/view Article Title Vitamin A, zinc and lung cancer.Authors S. Atukorala; T. K. Basu; J. W. Dickerson; D. Donaldson; A. SakulaAbstract Serum vitamin A concentration were measured in 26 newly diagnosed lung-cancer patients and found to be significantly lower than those of patients of similar age with either non-malignant lung or non-lung diseases. The levels of vitamin A in the lung-cancer patients, but not in the controls, were significantly correlated with serum concentrations of retinol-binding protein (RBP) and zinc. It is suggested that low levels of zinc might reduce the synthesis of RBP and thus reduce the mobilization of vitamin A from the liver.Is Part Of British Journal of Cancer 1979-12-01 , Vol.40 (6) , 927-931 Identifier ISSN: 1532-1827, 0007-0920 Category -
PMC OpenAccess
Subject 의과학, 인문사회과학 Source PMC OpenAccess URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010134/view Article Title The carcinogenicity of 15,16-dihydro-11-methyl-cyclopenta[a]phenanthren-17-one.Authors M. M. Coombs; T. S. Bhatt; S. YoungAbstract Direct comparison of skin-tumour induction by 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one (I) and by benzo[a]pyrene on mouse skin, both by repeated application or by initiation with a single dose followed by promotion with croton oil, demonstrated that these two carcinogens have similar potency. After repeated application of (I) the mean latent period for skin-tumour induction was linearly related to the logarithm of the dose over a 10-fold dose range. Under these conditions, application of the aryl-hydrocarbon-hydroxylase inhibitor 7,8-benzoflavone together with (I) inhibited tumour induction by about 40%. By contrast, in the 2-stage experiment, little effect on tumour incidence or latent period was observed when this inhibitor was applied with the single initiating dose of (I). Co-administration of the epoxide-hydratase inhibitor 1,1,1-trichloropropene oxide caused enhancement by shortening the latent period. After s.c. injection of (I) into mice, a similar number of tumours was induced on skin remote from the site of injection by promotion with corton oil begun either one week or 6 months after initiation. Gastric instillation of (I) into female rats induced mammary adenocarcinomas.Is Part Of British Journal of Cancer 1979-12-01 , Vol.40 (6) , 914-921 Identifier ISSN: 1532-1827, 0007-0920 Category -
PMC OpenAccess
Subject 의과학, 인문사회과학 Source PMC OpenAccess URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010143/view Article Title Paraneoplasia: Biological Signals in the Diagnosis of CancerAuthors R. C. CoombesIs Part Of British Journal of Cancer 1979-12-01 , Vol.40 (6) , 959-960 Identifier ISSN: 1532-1827, 0007-0920 Category -
PMC OpenAccess
Subject 의과학, 인문사회과학 Source PMC OpenAccess URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010128/view Article Title Fundamentals of Cancer ChemotherapyAuthors H. BushIs Part Of British Journal of Cancer 1979-12-01 , Vol.40 (6) , 960-961 Identifier ISSN: 1532-1827, 0007-0920 Category