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- :: PLOS A screening of the MMV Pathogen Box® reveals new potential antifungal drugs against the etiologic agents of chromoblastomycosis Chromoblastomycosis (CBM) is a chronic subcutaneous mycosis caused by traumatic implantation of many species of black fungi. Due to the refractoriness of some cases and common recurrence of CBM, a more effective and less time-consuming treatment is mandatory. The aim of this study was to identify compounds with in vitro antifungal activity in the Pathogen Box® compound collection against different CBM agents. Synergism of these compounds with drugs currently used to treat CBM was also assessed. An initial screening of the drugs present in this collection at 1 μM was performed with a Fonsecaea pedrosoi clinical strain according to the EUCAST protocol. The compounds with activity against this fungus were also tested against other seven etiologic agents of CBM (Cladophialophora carrionii, Phialophora verrucosa, Exophiala jeanselmei, Exophiala dermatitidis, Fonsecaea monophora, Fonsecaea nubica, and Rhinocladiella similis) at concentrations ranging from 0.039 to 10 μM. The analysis of potential synergism of these compounds with itraconazole and terbinafine was performed by the checkerboard method. Eight compounds inhibited more than 60% of the F. pedrosoi growth: difenoconazole, bitertanol, iodoquinol, azoxystrobin, MMV688179, MMV021013, trifloxystrobin, and auranofin. Iodoquinol produced the lowest MIC values (1.25–2.5 μM) and MMV688179 showed MICs that were higher than all compounds tested (5 - >10 μM). When auranofin and itraconazole were tested in combination, a synergistic interaction (FICI = 0.37) was observed against the C. carrionii isolate. Toxicity analysis revealed that MMV021013 showed high selectivity indices (SI ≥ 10) against the fungi tested. In summary, auranofin, iodoquinol, and MMV021013 were identified as promising compounds to be tested in CBM models of infection.
- :: KOCW 형태인식론 This lecture will cover the basic concepts and principles of pattern recognition and introduce its various applications to help student understand what the pattern recognition is and how it can be used for their research.
- :: Phys.org Can't touch this! Video shows blacktip sharks use shallow water to flee huge predators It's "hammerhead" time according aerial drone footage of blacktip sharks fleeing to shallow waters when confronted by a huge predator along the coast of southeast Florida. Footage from the drone provides the first evidence of adult blacktip sharks (Carcharhinus limbatus) using shallow waters as a refuge from the great hammerhead shark, (Sphyrna mokarran)—proving you "can't touch this."
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[재공모]연구개발 시제업체 선정을 위한 제안서 재공모(과제명 : 잠수함 음향신호 감소를 위한 제어력 120N급 3축 능동마운트 설계기술)